Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

Phase 2

• Conditions: Plantar Wart
• Interventions: Drug: Pyruvic acid; Drug: Salicylic Acid

• Registration Number: NCT02151630
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

Plantar warts can be bothersome and painful requiring treatment. The investigators will compare the efficacy of pyruvic acid and salicylic acid in treating multiple plantar warts. Patients with multiple plantar warts will be randomized to receive either pyruvic acid 70% or compound salicylic acid solution (salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%) applying topically twice a day for 4 weeks. Patients will be visited every 2 weeks for one month after starting treatment and then every one month for up to 3 months. The number and size of warts will be evaluated.

Detailed Description

Not available

Study Timeline

• Status Verified: 2014-05
• Study Start: 2014-05
• Study First Submitted: 2014-05-28
• Study First Submitted QC: 2014-05-29
• Last Update Submitted: 2014-05-29
• Study First Posted: 2014-05-30
• Last Update Posted: 2014-05-30
• Primary Completion: 2014-09
• Study Completion: 2014-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• aged 12 years and above
• multiple warts (at least 2)

Exclusion Criteria

• mosaic warts
• already under any treatment for warts
• pregnant or lactating women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pyruvic acid	Pyruvic acid	Patients will receive pyruvic acid solution 70% prepared by solving of pyruvic acid in water/ethanol solution. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.
Salicylic acid	Salicylic Acid	Patients will receive a combination of salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.

Primary Outcome Measures

Name	Time	Method
Wart number	From before to 3 months after	Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the number of warts. Any wart totally non-detectable by inspection and touch will be considered as healed.
Wart size	From before to 3 months after	Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the size of warts. The size of the warts will be calculated as the mean size of all the warts.

Trial Locations

Locations (1)

Skin Diseases and Leishmaniasis Research Center; 🇮🇷 Isfahan, Iran, Islamic Republic of