The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function

Phase 1

Completed

• Conditions: Cardiovascular Disease
• Interventions: Dietary Supplement: Control; Dietary Supplement: Peanut

• Registration Number: NCT01405300
• Lead Sponsor: Penn State University

Brief Summary

Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal. However, it is unclear whether acute consumption of peanuts can also influence vascular function. This study will therefore evaluate the effects of acute peanut consumption on vascular function, glycemic control, and plasma lipids. The hypothesis is that that addition of peanuts to a high fat/high glucose meal will reduce the production of triglycerides, glucose, and improve endothelial function as measured by flow-mediated dilation (FMD).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-07-27
• Study First Submitted QC: 2011-07-28
• Study First Posted: 2011-07-29
• Study Start: 2011-08
• Primary Completion: 2014-05
• Study Completion: 2014-06
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-16
• Last Update Posted: 2023-08-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• 20-50 years of age
• LDL-C below 160 mg/dL
• Triglyceride below 350 mg/dL
• Blood pressure within normal ranges (below 140/90 mmHg)
• Not taking medication for elevated lipids, blood pressure or glucose

Exclusion Criteria

• Allergies to peanuts or dairy products
• Known intolerance for high fat meals
• History of cardiovascular disease (CVD), kidney disease, diabetes or inflammatory diseases such as GI disorders and arthritis
• Use of non-steroidal anti-inflammatories or immunosuppressants
• Conditions requiring the use of steroids
• Use of medication or supplements for elevated lipids, blood pressure or glucose
• Donation of blood or plasma during the study
• History of thyroid disease
• Women
• Lactose intolerance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control	Control	-
Peanut	Peanut	-

Primary Outcome Measures

Name	Time	Method
Change from baseline in Flow-Mediated Dilation at 4 hours postprandial	0 min; 240 min

Secondary Outcome Measures

Name	Time	Method
Change from baseline in serum insulin over 4 hours postprandial	0 min, 30 min, 60 min, 120 min, 240 min
Change from baseline in oxidative stress over 4 hours postprandial	0 min, 30 min, 60 min, 120 min, 240 min
Change from baseline in serum lipids over 4 hours postprandial	0 min, 30 min, 60 min, 120 min, 240 min
Change from baseline in serum glucose over 4 hours postprandial	0 min, 30 min, 60 min, 120 min, 240 min

Trial Locations

Locations (1)

Penn State University; 🇺🇸 University Park, Pennsylvania, United States