Exercise therapy and cognitive behavioural therapy in Postpoliomyelitis Syndrome: effects on fatigue, activities and quality of life.

Completed

• Conditions: Postpoliomyelitis Syndrome; PPS; 10029317

• Registration Number: NL-OMON35382
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 81

Inclusion Criteria

(1) diagnosis of PPS according to the criteria of March and Dimes i.e.
a. A confirmed history of paralytic poliomyelitis characterized by an acute illness with fever and a usually asymmetrically distributed, flaccid paresis of a varying number of muscle groups. Evidence of motor neuron loss on neurological examination with signs of residual weakness, atrophy, loss of tendon reflexes and intact sensation.
b. A period of partial or complete functional recovery after acute paralytic poliomyelitis, followed by an interval (usually 15 years or more) of stable neurologic function.
c. Gradual or sudden onset of progressive and persistent new muscle weakness or abnormal muscle fatigability (decreased endurance), with or without generalized fatigue, muscle atrophy, or muscle and joint pain. Symptoms persist for at least a year.
d. No other medical diagnosis to explain the symptoms (anemia and thyroid dysfunction
as a cause of fatigue will be ruled out by blood test).
(2) suffering from severe perceived fatigue (CIS-fatigue ><= 35)
(3) age between 18 and 70 years
(4) a life-expectancy longer than one year
(5) consultation (not necessarily the first consultation) of a neurologist or physical medicine and rehabilitation specialist in the previous 5 years
(6) walking-ability at least indoors with or without a walking aid
(7) ability to cycle on a bicycle ergometer against a load of at least 25 Watt.

Exclusion Criteria

(1) cognitive impairment
(2) insufficient mastery of the Dutch language
(3) pregnancy
(4) use of psychotropic drugs (except simple sleeping medication) or other psychiatric treatment.
(5) use of medication causing fatigue
(6) disabling co-morbidity interfering with the intervention programs or influencing outcome
parameters (including cardiopulmonary disease like chest pain, arrhythmia, pacemaker, cardiac surgery, severe dyspnoea d*effort or emphysema, epileptic seizures, poorly regulated diabetes mellitus).
(7) respiratory insufficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified