Relationship Between Effect Duration of Rocuronium and Body Composition Analysis Data.

• Conditions: Body Composition; Rocuronium
• Interventions: Device: body composition analysis

• Registration Number: NCT05515835
• Lead Sponsor: Samsung Medical Center

Brief Summary

The induction dose of rocuronium is typically decided based on the patient's body weight, but the effect duration of rocuronium is variable. Some studies suggest that body composition analysis data, such as skeletal muscle mass or total body water, may correlate better with the duration time of rocuronium. Therefore, we plan to analyse body composition in patients undergoing total intravenous general anesthesia, give the patients a fixed dose (50mg) of rocuronium, and check the correlation between duration time of rocuronium and body composition analysis data.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-08-22
• Study First Submitted QC: 2022-08-23
• Study First Posted: 2022-08-25
• Study Start: 2022-09-05
• Primary Completion: 2022-12-30
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-02
• Last Update Posted: 2023-01-04
• Study Completion: 2023-03

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• Adult patients with ASA class I-II undergoing total intravenous general anesthesia

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Exclusion Criteria

• too overweight (over 111.11kg, which corresponds to less than 0.45mg/kg of induction dose of rocuronium)
• too underweight (under 41.67kg, which corresponds to more than 1.2mg/kg of induction dose of rocuronium)
• pregnancy
• prediagnosed muscle or nerve related disease
• unsuitable for body composition analysis using bioelectrical impedance method
• unsuitable for neuromuscular block monitoring

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
rocuronium	body composition analysis	The patient will be given 50mg of rocuronium intravenously for induction.

Primary Outcome Measures

Name	Time	Method
time to TOF4	up to 1.5 hour after rocuronium administration during induction of anesthesia	correlation between the time from induction to recovery of 4th TOF twitch and age, sex, ASA class, body weight, and body composition analysis data
time to TOF1	up to 1 hour after rocuronium administration during induction of anesthesia	correlation between the time from induction to recovery of 1st TOF twitch and age, sex, ASA class, body weight, and body composition analysis data

Secondary Outcome Measures

Name	Time	Method
time to loss of TOF	up to 5 minutes after rocuronium administration during induction of anesthesia	correlation between the time from injection of rocuronium to complete loss of TOF twitch and age, sex, ASA class, body weight, and body composition analysis data

Trial Locations

Locations (1)

Samsung Medical Center, Sungkyunkwan University, School of Medicine; 🇰🇷 Seoul, Korea, Republic of