Effect of Thiamphenicol on EAAT2 and Other Biomarkers From Nasal Biopsied Tissue

Phase 1

Completed

• Conditions: Healthy
• Interventions: Drug: Placebo; Drug: Thiamphenicol

• Registration Number: NCT00958503
• Lead Sponsor: Psyadon Pharma

Brief Summary

The purpose of this study is to determine if two-weeks of dosing with thiamphenicol is safe and is able to change the levels of certain pre-specified biomarkers in nervous tissue taken from the nasal passages.

Detailed Description

Thiamphenicol has been proposed to increase the levels of the excitatory amino acid transporter 2 (EAAT2) in the nervous tissue. This study evaluated the ability of two weeks of treatment with thiamphenicol to increase EAAT2 in a nasal biopsy as a surrogate of brain nervous tissue.

Study Timeline

• Study Start: 2007-07
• Primary Completion: 2007-09
• Study Completion: 2008-04
• Study First Submitted: 2009-08-12
• Study First Submitted QC: 2009-08-12
• Study First Posted: 2009-08-13
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-24
• Last Update Posted: 2015-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• normal volunteers

Exclusion Criteria

• less than 18 years
• older than 55 years

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Placebo
Thiamphenicol	Thiamphenicol	Active comparator

Primary Outcome Measures

Name	Time	Method
Amount of EAAT2 RNA in nasal biopsy	Two weeks

Trial Locations

Locations (1)

SGS Research Unit - Stuivenberg; 🇧🇪 Antwerpen, Belgium