In-depth ECG Analysis for the Extraction of Biomarkers of Cardiac Mechanical Dispersion

Not yet recruiting

• Conditions: Cardiovascular Pathology
• Interventions: Device: ECG; Device: Echocardiography

• Registration Number: NCT06163911
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Left ventricular systolic dysfunction (LVSD) refers to impaired contraction of the left ventricle, and can lead to heart failure and death. Early identification of LVSD, which often remains asymptomatic for years, is therefore crucial to mitigate the associated risks through appropriate treatment. Echocardiographic screening of asymptomatic individuals is costly, requires access to experts, and the criteria for selecting potential high-risk individuals for screening remain unclear.

Unlike echocardiography, the electrocardiogram (ECG) is a relatively low-cost procedure, routinely available and requiring little technical training to set up the examination and collect data, making it an interesting tool for early detection of LVSD.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-12
• Study Start: 2023-12-01
• Study First Submitted: 2023-12-01
• Study First Submitted QC: 2023-12-01
• Last Update Submitted: 2023-12-01
• Study First Posted: 2023-12-11
• Last Update Posted: 2023-12-11
• Primary Completion: 2024-11-30
• Study Completion: 2025-06-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Person who has received full information on the organization of the research and has not objected to the use of this data;
• Age ≥ 50;
• Persons who have undergone an echocardiographic examination and a 12-lead ECG examination during consultations at the CHRU de Nancy;
• Persons with at least one cardiovascular risk (obesity, diabetes, hypertension, etc.).

Exclusion Criteria

• People with a history of heart disease (ischemic, valvular);
• Patients with significant 12-lead ECG abnormalities (complete bundle branch block, sequelae of myocardial infarction, etc.);
• ECG tracings or echocardiograms that cannot be analyzed.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Myocardial contractility abnormalities	Echocardiography	-
No myocardial contractility abnormalities	Echocardiography	-
No myocardial contractility abnormalities	ECG	-
Myocardial contractility abnormalities	ECG	-

Primary Outcome Measures

Name	Time	Method
F1 score for classification of cardiac contractility abnormalities	12 months

Trial Locations

Locations (1)

CHRU Nancy; 🇫🇷 Vandœuvre-lès-Nancy, CHRU De Nancy, France