Evaluation of the efficacy of Intraventricular injection Actilyse(rt-PA) on recovery of patients with Spontaneous Intraventricular Hemorrhage ( IVH )

Phase 3

Recruiting

• Conditions: Spontaneous Intraventricular Hemorrhage.; Nontraumatic intracerebral hemorrhage, intraventricular; I61.5

• Registration Number: IRCT20200729048251N1
• Lead Sponsor: Rasht University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 September 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients with diagnosis of spontaneous IVH
Patients with diagnosis of spontaneous IVH and deep ICH with a volume of less than 20 cc

Exclusion Criteria

All contraindications to the use of anticoagulants
Patients with known bleeding disorder
Patients with evidence of uncontrolled hypertension Systolic pressure greater than 180 or diastolic pressure greater than 110
Patients with evidence of acute pancreatitis
Patients with proven gastrointestinal ulcer disease in the last 3 months, esophageal varices, arterial aneurysms, venous arterial malformations
Recent severe and dangerous bleeding
Bacterial endocarditis and pericarditis
Neoplasms with an increased risk of bleeding
Severe liver disease such as liver failure, liver cirrhosis, increased portal vein pressure (esophageal varices) and active hepatitis
Major surgery or significant trauma in the last 3 months
Platelet count below 100,000
Recent extracorporeal trauma massage (less than 10 days), recent delivery, recent non-compressible vascular puncture such as subclavian or jugular vein

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recovery of patients with determining GCS and GOS. Timepoint: During hospitalization up to four months after discharge. Method of measurement: with determining GCS and GOS.