The Prognostic Value of Quantitative Parameters Derived From Dual Scanning of FDG and PSMA PET/CT for Tumor Progression in Patients With Metastatic Hormone-sensitive Prostate Cancer Receiving Novel Hormone Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Castration-Resistant Prostate Cancer free survival (CRPC-FS)
研究概览
简要总结
Investigators retrospectively collected data from consecutive patients treated at the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, from October 2020 to March 2024. The inclusion criteria were as follows: (1) patients with diagnosis of metastatic hormone-sensitive prostate cancer, confirmed by PSA levels, radiographic tests and pathological information; (2) patients who underwent FDG and PSMA PET/CT prior to the initiation of medical treatment. The exclusion criteria were as follows: (1) patients who received novel hormone therapy or a prostate biopsy prior to PET/CT; (2) patients with other malignancies; (3) patients received hormone therapy without NHT; (4) patients received chemotherapy or radiotherapy prior to or during novel hormone therapy; (5) absence of follow-up data at the hospital.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •patients with diagnosis of metastatic hormone-sensitive prostate cancer, confirmed by PSA levels, radiographic tests and pathological information
- •patients who underwent FDG and PSMA PET/CT prior to the initiation of medical treatment
排除标准
- •patients who received novel hormone therapy or a prostate biopsy prior to PET/CT
- •patients with other malignancies
- •patients received hormone therapy without novel hormone therapy
- •patients received chemotherapy or radiotherapy prior to or during novel hormone therapy
- •absence of follow-up data at our institution
结局指标
主要结局
Castration-Resistant Prostate Cancer free survival (CRPC-FS)
时间窗: From date of the initiation of novel hormone therapy until the date of first documented either PSA or radiography-confirmed progression or date of the last follow-up for any cause, whichever came first, assessed up to 100 months
次要结局
未报告次要终点
研究者
Zheng fufu
Professor, Phd, Md
Sun Yat-sen University
