Postoperative Venous Thromboembolism Risk in 140,831 Surgical Patients - a Genetic Association Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 502,505
- 试验地点
- 1
- 主要终点
- Postoperative VTE event
研究概览
简要总结
Postoperative Venous Thromboembolism Events (VTE) constitute a major source of morbidity and mortality after surgery. The aim of this study was to investigate whether commonly occurring Single Nucleotide Polymorphisms (SNPs) are associated with VTE in the surgical setting.
详细描述
Data extracted from the participants in the UK Biobank collaborative study. Two cohorts will be examined:
- Surgical cohort, consisting of all patients with a registered surgical procedure in the UK biobank repository
- Validation cohort, consisting of all non-surgical patients in the UK biobank repository.
A GWAS approach will be used to associated commonly occurring single nucleotide polymorphisms (SNPs) with a postoperative venous thromboembolic event (VTE) within 30 days of a surgical procedure in the surgical cohort.
Findings from the surgical GWAS step will be replicated in the Validation cohort in order to assess whether the same SNPs drive both surgical and non-surgical VTE risk.
A final GWAS model will be fielded, correction for confounders including sex, age, smoking, obesity and open/minimal invasive surgery (surgical discovery GWAS only).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients included in the UK biobank repository
- •Exclusion criteria:
排除标准
- 未提供
结局指标
主要结局
Postoperative VTE event
时间窗: 30 days of a surgical procedure
次要结局
未报告次要终点
研究者
Martin Sillesen
Assoc. Prof.
Rigshospitalet, Denmark