Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis

• Conditions: Sepsis

• Registration Number: NCT01535534
• Lead Sponsor: Universitätsmedizin Mannheim

Brief Summary

During the past years many investigators have focused on the immunological changes in sepsis disease, and great attention has been paid to the development of practicable means of immunomonitoring. Little is known about diagnostic and prognostic vascular biomarkers during the time course of patients with sepsis.

Detailed Description

Primary Outcome Measures:

New diagnostic and prognostic markers for septic patients

Estimated Enrollment: 300 patients Study Start Date: January 2012 Estimated Study Completion Date: open Estimated Primary Completion Date: open

Intervention Details:

Procedure: vein puncture comparison of different inflammatory markers in the blood of septic patients

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-02-14
• Study First Submitted QC: 2012-02-16
• Study First Posted: 2012-02-17
• Primary Completion: 2018-12
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-26
• Last Update Posted: 2020-08-27
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• SIRS-Criteria
• Proven Infection
• One sepsis-induced organ-failure
• Adults < 18 years old

Exclusion Criteria

• Anemia
• Pregnancy
• Blood donor in the last 3 month

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

University Medical Centre Mannheim; 🇩🇪 Mannheim, Baden-Württemberg, Germany