Pregnancy Related Inappropriate Sinus Tachycardia Syndrome Study
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Feasibility of examining autonomic function and related haemodynamic variables in pregnant women with and without inappropriate sinus tachycardia
研究概览
简要总结
A feasibility study into the exploration of possible mechanisms underlying inappropriate sinus tachycardia (IST) syndrome in pregnancy.
详细描述
This is a non-interventional, physiological study which will explore the feasibility of examining autonomic function and related haemodynamic variables in pregnant women with and without inappropriate sinus tachycardia, with the aim of providing scope for future research.
Sinus tachycardia (normal heart rhythm but fast heart rate) is common and usually related to an obvious cause (e.g. exercise such a running or cycling) and doesn't cause any untoward symptoms. In rare cases however, sinus tachycardia can occur without an obvious cause (i.e. it is inappropriate to the situation) and can cause distressing symptoms such as palpitations, dizziness and breathlessness at rest or with minimal exertion. This syndrome of inappropriate sinus tachycardia is poorly understood and can be difficult to manage; especially when the affected individual is pregnant. In order to understand the condition better and improve care pathways we aim to measure various features of the cardiovascular system in pregnant women with and without IST.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Aged 18-45 years of age
- •Able to give written informed consent and willing to participate
- •The participant falls into one of the below categories:
- •i. Pregnant women with IST ii. Pregnant women without IST
排除标准
- •Obesity (BMI > 29.9)
- •Current or recent (within last 3 months) smoker
- •Known medical condition likely to affect HRV (other than IST in relevant groups)
- •Previous history of hypertensive disorders in pregnancy
- •Lack of written informed consent
结局指标
主要结局
Feasibility of examining autonomic function and related haemodynamic variables in pregnant women with and without inappropriate sinus tachycardia
时间窗: Up to 3 years
Number of women in each group who agree to participate in the study
Assessment of autonomic function and related haemodynamic variables in pregnant women with and without inappropriate sinus tachycardia
时间窗: Up to 3 years
Baroreflex sensitivity (BRS) at rest calculated from the change in systolic pressure and change in R-R interval to give change in pressure per change in RR interval, measured in milliseconds (mmHg/ms)
次要结局
- Assessment of ANS function in pregnant women with and without IST, at rest and during mild exercise(Up to 3 years)
研究者
Dr Mark Belham
Consultant Cardiologist
Cambridge University Hospitals NHS Foundation Trust
