Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study
Not Applicable
Recruiting
- Conditions
- Postpartum Hemorrhage
- Registration Number
- NCT05290129
- Lead Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
Inclusion Criteria:<br><br>• All patients with induced or augmented labour undergoing cesarean delivery under<br>neuraxial anesthesia (at least 3 hours of prior exposure to oxytocin during labour)<br><br>Exclusion Criteria:<br><br> - All patients who refuse to give written informed consent<br><br> - All patients who declare allergy or hypersensitivity to oxytocin<br><br> - A history of hypertension and/or severe cardiac disease(s)<br><br> - All patients who have contraindications for neuraxial anesthesia<br><br> - All patients who will be converted to general anesthesia intraoperatively<br><br> - All patients with placenta previa and multiple gestation
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Uterine tone up to discharge from the post anesthetic care unit (PACU): questionnaire
- Secondary Outcome Measures
Name Time Method Calculated blood loss;Need for blood transfusion;Episodes of bleeding postpartum;Intraoperative requirement for additional uterotonic medication;Requirement for additional uterotonic medication in the PACU;Requirement for additional uterotonic medication from discharge from the PACU until 24 hours postpartum.;Hypotension: systolic blood pressure less than 80% of baseline;Hypertension: systolic blood pressure greater than 120% of baseline;Tachycardia: heart rate greater than 130% of baseline;Bradycardia: heart rate less than 70% of baseline;Presence of ventricular tachycardia: ECG;Presence of atrial fibrillation: ECG;Presence of atrial flutter: ECG;Presence of nausea: questionnaire;Presence of vomiting: questionnaire;Presence of chest pain: questionnaire;Presence of shortness of breath: questionnaire;Presence of headache: questionnaire