A Study to Observe the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) as an Augmentation Therapy in Pharmaco-resistant OCD
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- To observe the Effect of repetitive transcranial magnetic stimulation in YBOCS score in patients of pharmaco-resistant OCD
研究概览
简要总结
OCD is a frequent and disabling psychiatric disorder with a lifetime prevalence of 1-3%. Approximately 40-60% of OCD patients remain treatment refractory to current first line therapies. Repetitive transcranial magnetic stimulation is a non invasive brain stimulation technique proposed as a promising treatment via its neuroplastic effects. This study aims to observe the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as an augmenting treatment method in treatment refractory patients.Kindly consider for CTRI registration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Response failure to previous or current use of medication or psychotherapy ( response failure was defined as scores more than 16 at Y BOCS despite atleast two SSRI trials of adequate dose and duration)
- •Stable medication regimen 8- 10 weeks before the intervention and unchanged during the treatment (4-6weeks).
排除标准
- •Previous treatment with electroconvulsive therapy, and presence or history of psychosis, substance abuse, suicide attempt and or active suicide ideation, neurological disorder, epilepsy, seizures, and head injury or loss of consciousness
- •According to the safety criteria for rTMS, patients with implanted devices, metal bodies, cardiac arrhythmia, unstable medical conditions, or pregnancy, were also excluded.
- •Patients diagnosed with any other comorbid psychiatric illness except depression and anxiety
- •Patients diagnosed with any other chronic physical illness.
结局指标
主要结局
To observe the Effect of repetitive transcranial magnetic stimulation in YBOCS score in patients of pharmaco-resistant OCD
时间窗: After 25th session of rTMS
次要结局
- Changes in Y BOCS , HAM-A and HAM-D scores(After 10th , 15th and 20th session of rTMS)
研究者
Dr Suresh Chand Gocher
RNT Medical College and MB Hospital