A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia

Recruiting

• Conditions: Anesthesia

• Registration Number: NCT05954832
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. The researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressure (hypotension) after receiving anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-13
• Study First Submitted: 2023-07-13
• Study First Submitted QC: 2023-07-13
• Study First Posted: 2023-07-20
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-25
• Last Update Posted: 2025-06-26
• Primary Completion: 2027-07
• Study Completion: 2027-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• Adult patients ≥ 18 years of age requiring general anesthesia for surgery
• Intubation required for anesthetic management / surgery
• Anticipated prep time before incision of 20 minutes
• Baseline MAP >70mmHg

Exclusion Criteria

• History of coronary artery disease
• History of cardiac disease (e.g., HTN, arrythmias, valvular and structural abnormalities)
• History of peripheral artery occlusive disease
• Beta-blocker use
• Anti-hypertensive medication use
• Patients with epidural, spinal, paravertebral, serratus blocks preoperatively
• Patients requiring rapid sequence induction (where intubation occurs concurrently with induction)
• Emergency surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The proportion of patients with post-induction hypotension (PIH)	up to 20-mins after anesthesia induction.	summarize the distributions of the echocardiography parameter values (pre-load LVEDd(cm), after-load LVEDs(cm), other measures \[e.g., contractility (EF %) and structural abnormalities\]) across each timepoint among patients with and without PIH

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center (All protocol activites); 🇺🇸 New York, New York, United States