Effects of Parmigiano Reggiano on Exercise Induced Muscle Damage in Older Adults
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- maximum volountary contraction (MVC)
研究概览
简要总结
Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity.
Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle to combine high muscle strength production with low energy cost. ECC contractions are significantly more damaging to the muscles and produce greater muscle strength, for these reasons there is a greater risk of inducing muscle damage before the muscle is able to adapt.
Parmigiano Reggiano (PR) has some peculiar bromatological characteristics. The proteins contained in it, and in particular the potentially bioactive peptide sequences, can rapidly provide the amino acids necessary to promote muscle growth and repair during exercise. Furthermore, PR can be an important source of fatty acids, of which a significant amount of short-chain fatty acids (SCFA) which are known to have important clinical effects on body composition and metabolic health and can have a systemic anti-inflammatory effect.
Therefore, the central hypothes is that PR consumed during RET can provide more energy substrates and improve muscle recovery. To date, no studies have studied its function on recovery from exercise nor in the elderly.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age >60 years old or >18 and < 30 years old
- •BMI >18 and <30 kg/m2
- •stable body weight in the past 3 months
- •valid medical certifacate for practice of physical activity
排除标准
- •diabetes or pre-diabetes as for ADA guidelines
- •chronic diseases (cardiovascular, liver, respiratory, cancer, etc)
- •acute inflammatory status
- •regular practice of intense physical activity (>2 sessions/week)
- •treatment with steroids in the past 3 months
- •regular use of >50g/die of Parmigiano Reggiano
研究组 & 干预措施
Young adults
participants will perform an eccentric exercise bout after 10 days of dietary supplementation
干预措施: Whey Protein (Dietary Supplement)
Young adults
participants will perform an eccentric exercise bout after 10 days of dietary supplementation
干预措施: Parmigiano Reggiano (Dietary Supplement)
Older adults
participants will perform an eccentric exercise bout after 10 days of dietary supplementation
干预措施: Parmigiano Reggiano (Dietary Supplement)
Older adults
participants will perform an eccentric exercise bout after 10 days of dietary supplementation
干预措施: Whey Protein (Dietary Supplement)
结局指标
主要结局
maximum volountary contraction (MVC)
时间窗: Change from baseline to up to 5 days
maximal muscle volountary contraction mesured in Newton
次要结局
- Creatin Kinase(Change from baseline to up to 5 days)
- reactive Proteinc C(Change from baseline to up to 5 days)
- IL-6(Change from baseline to up to 5 days)
- delayed onset muscle soreness (DOMS)(Change from baseline to up to 5 days)
