Distribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality. The DIGNITY Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardial Infarction
- Sponsor
- University Hospital Southampton NHS Foundation Trust
- Enrollment
- 1500
- Locations
- 1
- Primary Endpoint
- Association between high sensitivity troponin and inpatient mortality on all patients admitted to each of the ICU environments at a large teaching hospital
- Last Updated
- 6 years ago
Overview
Brief Summary
The current diagnostic criteria for a heart attack require evaluation of a patient's symptoms and ECG but importantly a blood test called troponin. With advancing technology this test has become more sensitive and is now called a high sensitivity troponin. This is a very effective way of rapidly excluding a heart attack if the test is negative. However there are a number of causes of a raised high sensitivity other than a heart attack, particularly critical illness states. In the absence of features of a heart attack an abnormal result therefore suggests that the heart is inflamed or unwell causing the release of high sensitivity troponin. The DIGNITY study will examine the consequences of high sensitivity troponin elevation in patients in intensive care and assess whether it has a role as a biomarker for predicting outcome.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patients (aged 18 years or older) admitted to any of the three intensive care facilities on site (general, cardiac and neurosciences)
- •Biochemistry samples already taken as part of routine clinical care during the ICU stay
Exclusion Criteria
- •Patients aged less than 18 years
- •No biochemistry samples taken within the ICU stay
Outcomes
Primary Outcomes
Association between high sensitivity troponin and inpatient mortality on all patients admitted to each of the ICU environments at a large teaching hospital
Time Frame: During intensive care admission
Secondary Outcomes
- Association between high sensitivity troponin results and duration of ventilation(Within twenty eight days)
- Association between high sensitivity troponin results and length of intensive care admission(Number of days not in intensive care within twenty eight days of original intensive care admission)
- Distribution of high sensitivity troponin results for different admissions to intensive care(During intensive care admission)
- Association between high sensitivity troponin results and requirement for inotropic support(During intensive care admission)