The Effect of Aging and Immobilisation on Muscle
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Bispebjerg Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation
Study Overview
Brief Summary
The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 80 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)
Exclusion Criteria
- •Musculoskeletal disorder
- •Cardiovascular disease
- •Neurological diseases; or
- •Cognitive disorders
Arms & Interventions
1
9 healthy elderly males
Intervention: 2 weeks of unilateral immobilisation and 4 weeks of resistance training (Other)
2
11 healthy young males
Intervention: 2 weeks of unilateral immobilisation and 4 weeks of resistance training (Other)
Outcomes
Primary Outcomes
muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation
Time Frame: 2 weeks of immobilisation and 4 weeks of resistance training
Secondary Outcomes
- single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number(2 weeks of imm and 4 weeks of resistance training)