Transcranial Direct Current Stimulation of the Primary Motor Cortex to Treat Levodopa-induced Dyskinesias in Patients With Parkinson's Disease.
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Reduction of dyskinesia
Study Overview
Brief Summary
The main objective of the study is to evaluate the efficacy of 10 sessions of transcranial direct current stimulation of the primary motor cortex to reduce levodopa-induced dyskinesia
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 30 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients with diagnosis of idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria and levodopa-induced dyskinesia;
- •age between 30 and 80 years;
- •ongoing therapy with levodopa;
- •fulfillment of requirements for the application of transcranial magnetic stimulation (TMS), assessed by completion of the TMS screening questionnaire.
Exclusion Criteria
- •patients unable to give informed consent;
- •cognitive impairment (MMSE ≤ 24);
- •history of epilepsy;
- •pregnant women.
Arms & Interventions
Active stimulation
Ten sessions of cathodic transcranial direct current stimulation over primary motor cortex
Intervention: Transcranial direct current stimulation (Device)
Sham stimulation
Ten sessions of sham stimulation over primary motor cortex
Intervention: Transcranial direct current stimulation (Device)
Outcomes
Primary Outcomes
Reduction of dyskinesia
Time Frame: 15 days
Change in the total score of part III of the Unified Dyskinesia Rating Scale (range 0-112, 112 is the worse outcome) in on motor state at the assessment made three days after the end of treatment compared with the assessment made at baseline in the groups of patients treated with tDCS and sham-stimulation, respectively
Secondary Outcomes
No secondary outcomes reported