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临床试验/NCT02221193
NCT02221193已完成早期 1 期

Site-Specific Mouth Rinsing to Improve Oral Odor by Altering Bacterial Counts: Blind Crossover Clinical Study

Al-Baha University0 个研究点目标入组 20 人开始时间: 2013年7月最近更新:
适应症

试验速览

阶段
早期 1 期
状态
已完成
入组人数
20
主要终点
viable anaerobic and aerobic bacterial counts

研究概览

简要总结

Objectives: To determine whether site-specific mouth rinsing with oral disinfectants can improve oral odor beyond the traditional panoral mouth disinfection with mouth rinses by targeting specifically oral malodor implicate anaerobic bacteria.

Methods: Twenty healthy fasting subjects volunteered for a blinded prospective, descriptive correlational crossover cross-section clinical trial conduct during the month of Ramadan in the lunar Hajri year 1434 AH (10 July 2013-8 August 2013) in Albaha province in Saudi Arabia involving the application of Listerine® Cool Mint® mouth rinse by either the traditional panoral rinsing method or a site-specific disinfection method targeting the subgingival and supragingival plaque and the posterior third of the tongue dorsum while avoiding the remaining locations within the oral cavity. The viable anaerobic and aerobic bacterial counts, volatile sulfur compounds (VSCs) levels, organoleptic assessment of oral odor and the tongue-coating index were compared at baseline, 1, 5 and 9 hours after the treatment.

研究设计

研究类型
Interventional
干预模型
Crossover
主要目的
Supportive Care
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
17 Years 至 65 Years(Child, Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • Saudi Arabia volunteers to be recruited from Albaha province of Saudi Arabia via an online invitation on the e-learning blog www.alqumber.wordpress.com
  • No antibiotic usage and no antiseptic mouth rinse use for the last 3 months and one week preceding the commencement of the study, respectively.
  • Must be dentate healthy Saudi males aged 17-65 years, who adhere to the ritual of fasting.
  • provided informed consent form.

排除标准

  • Receiving any professional periodontal treatments (prophylactic scaling, root planning, and periodontal surgery) or professional advice during the previous year.
  • Prior to the inception of the study.

结局指标

主要结局

viable anaerobic and aerobic bacterial counts

时间窗: one month

Measuring bacterial numbers by culturing of saliva samples

assessment of oral odor

时间窗: one month

the mouth odor was assisted by smelling

volatile sulfur compounds (VSCs) levels

时间窗: one month

these compound measured in part per million

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dr Mohammed Abdullah Alqumber

Assistant Professor

Al-Baha University

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