NCT02037945已完成不适用
18F-Fluorocholine (18F-FCho) to Distinguish Necrosis From Recurrence in Brain Metastases
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- to distinguish radiation necrosis from progressive tumor
研究概览
简要总结
The main purpose of this study is to determine the distribution of 18F Fluorocholine (18F-FCH) in the brain which can help distinguishing radiation-induced scarring from tumor regrowth. In addition, the study will measure levels of 18F-FCH in the blood and (if applicable) in the brain lesion tissue that is removed as part of the planned brain surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient and/or guardian is able to provide written informed consent prior to study registration
- •Age ≥ 21 years old
- •Evolving brain lesions post SRS requiring neurosurgical resection (whether for symptomatic control or to establish pathology)
排除标准
- •Inability to undergo a MRI or PET scan (e.g., claustrophobia or metal implant)
- •Pregnant or nursing female
- •Unable to cooperate for PET/CT
结局指标
主要结局
to distinguish radiation necrosis from progressive tumor
时间窗: 1 year
by comparing the PET imaging results to the surgical pathology
次要结局
未报告次要终点
研究者
研究点 (1)
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