EARLY DETECTION OF DEAFNESS IN A MEMORY CENTER
- Conditions
- DeafnessCognitive Disorder
- Interventions
- Diagnostic Test: VRB test
- Registration Number
- NCT06088953
- Lead Sponsor
- University Hospital, Lille
- Brief Summary
Age-related hearing loss (ARHL), like neurodegenerative diseases, appears insidiously with age. As major public health issues, they are nonetheless under-diagnosed because the presence of one can hinder the objectification of the other.
The CogAudio project aims to detect early and in an ambulatory mode in a memory centre a speech perception disorder in noise thanks to the VRB test in patients weakened by cognitive disorders.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Patient with mild to moderate cognitive impairment, with an MMSE score ≥15/30
- Patient mastering the French language
- Patient who has given written consent to participate in the trial
- Socially insured patient
- Patient willing to comply with all study procedures and duration
- Patient accompanied by a study partner
- Medical history of diagnosed deafness, fitted or not
- History of progressive otological pathology or presence of tympanic obstruction (>1/3 of the surface of the eardrum)
- History of unstabilized psychiatric pathology
- Major visual impairment (Age-Related Macular Degeneration AMD...)
- Established diagnosis of major language disorders (Primary Progressive Aphasia APP...)
- Major under legal protection measure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description perception disorder in noise in patients weakened by cognitive disorders. VRB test The CogAudio project aims to detect early and in an ambulatory mode in a memory centre a speech perception disorder in noise thanks to the VRB test in patients weakened by cognitive disorders.
- Primary Outcome Measures
Name Time Method Ability of the VRB test to detect deafness in patients over 50 with mild to moderate cognitive impairment. 3 months Area under the ROC (receiver operating characteristic) curve of the VRB test for hearing loss screening.
- Secondary Outcome Measures
Name Time Method Frequency of patients with hearing aids at 12 months. 3 months or 12 months Frequency of patients with hearing aids at 12 months from inclusion
correlation between the hearing loss and the auditory discomfort (complaint) expressed by the patient and that observed by the caregiver 3 months or 12 months Hearing loss is defined by the VRB test score. The auditory complaint expressed by the patient is defined by the score on the HHIE-S questionnaire completed by the patient himself; the auditory complaint noted by the entourage is defined by the score on the adapted HHIE-S questionnaire completed by the caregiver present at the consultation at M0.
Evolution of the cognitive and functional profile at 12 months between patients with deafness and patients without deafness. 3 months or 12 months Variation in scores between M0 and M12 on EQ-5D-3L neuropsychological test.
To assess the diagnostic values of the VRB threshold associated with a disorder of speech comprehension in noise defined in the general population to screen for deafness in patients over 50 years of age with mild to moderate cognitive impairment. 3 months or 12 months Sensitivity, specificity, negative and positive predictive values of the pathological threshold defined in the general population (\>3 BSR ) for hearing loss screening (as defined in the primary endpoint)
To assess the correlation between an objective cortical marker of selective attention (long latency evoked potentials: P300 wave amplitude; patients' ability to discriminate sounds in silence), and subjects' performance in tone audiometry in silence 3 months or 12 months Amplitude and latency of the P300 wave; Tone audiometry score in silence.