Hemodynamic adaptation of the right ventricle in monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome or selective growth restrictio

Completed

• Conditions: heart failure; pulmonary stenosis; 10010394; 10016849; 10028971

• Registration Number: NL-OMON41328
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-11-30
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 188

Inclusion Criteria

* All women pregnant of monochorionic twins
* Ability to give informed consent

Exclusion Criteria

* Fetuses with non-cardiac congenital anomalies
* Fetuses with chromosomal abnormalities
* Maternal age < 18 years

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The size and growthpattern of the pulmonary artery at the level of the valve,<br /><br>expressed in standard deviations from the mean (according to Shapiro et al.28). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. The growth curve of the pulmonary artery, the maximum velocity (Vmax) curve<br /><br>of the pulmonary artery and veins in<br /><br>- TTTS or sIUGR with development of RVOTO .<br /><br>- TTTS or sIUGR without development of RVOTO.<br /><br>- Twins of uncomplicated MCDA pregnancies<br /><br>2. The MPI and Tissue Doppler of the myocard of the right ventricle in fetusses<br /><br>in complicated monochorionic twin pregnancies, compared with fetusses in<br /><br>uncomplicated monochorionic twin pregnancies.</p><br>