A clinical trial to study the effect of Yashtimadhu Taila Nasya in the management of premature graying of hair

Recruiting

• Conditions: Variations in hair color. Ayurveda Condition: AKALAPALITAH/PALITAH,

• Registration Number: CTRI/2022/05/042945
• Lead Sponsor: Dr Kamalpreet Kaur Virdi

Brief Summary

The face of an individual is a personal identity in which hair play a significant role. Healthy hair is a healthy sign of personality and youth. Everyone wants to look younger than their age and first thing they do is to hide their gray hair either by dyeing or some other ways. There is always a solution to every problem, same applies to canities (gray hair). So there is need to find a solution to make these canities to revert back to normal hair or stop the process of premature graying of hair. *Akal Palitya or* premature graying of hair is a disease pertaining to head and *Nasya* has been mentioned effective in *Shiroroga*. The information about the concept of *Nasyakarma* in *Panchakarma* and its importance is mentioned very well in *Ayurvedic Samhita Granthas*.  In *ayurveda* nose is considered as the gateway of the head. The process of giving medication through nose is called *Nasyakarma.* It is considered as the best route of medication for the ailments pertaining to head. *Acharya Sushrut,* while mentioning the *guna* and importance of *Nasya*, has mentioned that *Nasya* is effective in *Palitya rog* in Sh.Ch. 40/22 . *Acharya Cakardatta* has mentioned *Yashtimadhu Taila*in 59th chapter, *Netrarog Chikitsa.* It has been told thattaking *nasya* of this *taila* for one month will make visionclear and make  wrinkles and gray hairdisappear. Therefore *Nasya* is selected as route of administration for medication in *Akal Palitya* for clinical study. So this study will answer these questions of reversibility, stagnation of canities along with effectiveness of *Nasya* in *Akal Palitya* shall also be tested.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-06
• Last Update Posted: 2023-01-04

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patient aged between 15-35 years with premature graying of hair.
• Patient fit for Nasya 3.
• Patient of either sex 4.
• Patient willing to participate in the study.

Exclusion Criteria

• Patients with any systemic disorder 2.
• Patients with any skin disease like albinism, leucoderma or vitiligo 3.
• Patients with hereditary disorder (Werner’s syndrome: diagnosis will be done on clinical grounds through thorough history of patient) 4.
• Patients with hormonal imbalance like hyperthyroid or hypothyroid 5.
• Patient with Megaloblastic Anemia 6.
• Any autoimmune disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
White hair3	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
1.Kesha varna(color of hair)Natural color of hair0	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
2.Ruksha sphuttita kesha(dry split ends)	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Normal0	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Yellowish2	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Outcome will be assessed on following criteria and their respective scoring	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Dryness felt by touch2	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Split ends3	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Ash colored1	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Visible dryness1	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
(burning sensation)	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
3.Sanighad sthula (unctuous thick hair)	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Unctuous visible1	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Unctuous felt with	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Unctuous felt by touch2	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
No burning sensation0	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
split hair3	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
4.Daha over scalp	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Mild burning sensation 1 (localized)	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Severe burning sensation 3 (all over the scalp)	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up
Moderate burning sensation 2	Day 0: At the time of enrollment of patient for study | Day 30: At the end of treatment | Day 45: At first Follow up | Day 60: At second Follow up

Secondary Outcome Measures

Name	Time	Method
Random hair count will be done for counting number of gray hair. Scalp will be divided into five regions i.e. Frontal, Vertex, Right and Left Temporal and Occipital. One square centimeter area of scalp will be chosen where more gray hair are present, from this site gray hair would be counted randomly before and after the treatment.	Scoring of gray hair will be as follows:

Trial Locations

Locations (1)

Dayanand Ayurvedic Hospital; 🇮🇳 Jalandhar, PUNJAB, India

Dayanand Ayurvedic Hospital

🇮🇳Jalandhar, PUNJAB, India

Dr Parveen Kumar

Principal investigator

7589303536

drparv1@gmail.com