Physical Activity, Insulin Resistance and Function of Fat Tissue in the Offspring of Patients With Type 2 Diabetes

Not Applicable

Completed

• Conditions: Type 2 Diabetes Mellitus; Cardiovascular Diseases

• Registration Number: NCT00268541
• Lead Sponsor: NHS Greater Glasgow and Clyde

Brief Summary

Offspring of patients with type 2 diabetes have increased risk of developing diabetes and are typically more insulin resistant than their peers with no diabetes family history. We have recently demonstrated that, in contrast to their sedentary counterparts, physically active offspring are not insulin resistant. In the proposed controlled clinical study, we will examine the effects of a moderate exercise programme on insulin resistance, and other metabolic risk factors, in sedentary offspring and matched control subjects. We hypothesise that offspring will exhibit an augmented response to exercise, thereby normalising their predisposition to an adverse metabolic profile. We will also investigate expression of adipokines and other genes in adipose tissue to determine whether these contribute to the increased insulin resistance observed in offspring and whether they are influenced by exercise. The results will help to determine the efficacy of exercise in normalising metabolism in offspring and will help elucidate the mechanisms involved.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-09
• Study First Submitted: 2005-12-21
• Study First Submitted QC: 2005-12-21
• Study First Posted: 2005-12-22
• Study Completion: 2007-02
• Status Verified: 2007-04
• Last Update Submitted: 2007-04-19
• Last Update Posted: 2007-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• 2 subject groups - 'control' and 'offspring'
• Offspring - at least 1 parent diagnosed with type 2 diabetes before age 65
• Controls - no history of type 2 diabetes in 1st or 2nd degree relatives
• In generally good health
• Non-smoker
• Fasting glucose < 7 mmol/l
• Blood pressure <160/90 mm Hg
• No established CHD (e.g. MI, stroke, CABG, PCTA)

Exclusion Criteria

• Established CHD (e.g. MI, stroke, CABG, PCTA)
• diabetes
• smoking
• hypertension (BP > 160/90 mmHg)
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Insulin resistance at 8 weeks
Risk markers for cardiovascular disease/diabetes at 8 weeks
Adipose tissue gene expression at 8 weeks

Secondary Outcome Measures

Name	Time	Method
Fitness at 8 weeks
Body composition/adiposity at 8 weeks

Trial Locations

Locations (1)

University of Glasgow; 🇬🇧 Glasgow, United Kingdom