NCT02701127已完成早期 1 期
Molecular Effects of Vitamin B3 (Niacinamide) in Acute Kidney Injury
适应症
干预措施
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Changes from baseline in serum metabolite profile of niacinamide
研究概览
简要总结
This is a single center, randomized, single-blind, placebo-controlled study to evaluate the safety and biochemical effects of niacinamide on metabolic parameters of the kidney in patients undergoing cardiac surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Niacinamide 1 gram
Active Comparator
Oral niacinamide, 1 gram daily
干预措施: Oral niacinamide, 1 gram daily (Drug)
Niacinamide 3 grams
Active Comparator
Oral niacinamide, 3 grams daily
干预措施: Oral niacinamide, 3 gram daily (Drug)
Placebo
Placebo Comparator
Oral placebo pill
干预措施: Placebo (Drug)
结局指标
主要结局
Changes from baseline in serum metabolite profile of niacinamide
时间窗: Baseline and days 1 through 4
次要结局
- Changes from baseline in urine metabolite profile of niacinamide(Baseline and days 1 through 4)
研究者
Ali Poyan Mehr
Instructor in Medicine
Beth Israel Deaconess Medical Center
研究点 (1)
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