A randomised controlled trial of tea tree oil (5%) body wash versus standard body wash to prevent colonisation with methicillin-resistant Staphylococcus aureus in critically ill adults
Completed
- Conditions
- Critical illnessMethicillin-Resistant Staphylococcus Aureus (MRSA)Infections and InfestationsStaphylococcus infection
- Registration Number
- ISRCTN65190967
- Lead Sponsor
- Belfast Health and Social Care Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 1080
Inclusion Criteria
Patients admitted to the Intensive Care Unit (ICU) during the study period will be eligible for inclusion in the study.
Exclusion Criteria
1. Aged less than 16 years
2. Those patients who are known to be colonised at the time of admission
3. Patients who on admission are unlikely to remain in the Respiratory Intensive Care Unit (RICU) for at least 48 hours
4. Patients who are recruited, whose pre-intervention MRSA screening tests are subsequently found to be positive, will be withdrawn from the study
5. Consent declined
6. Known sensitivity to TTO
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ew MRSA colonisation during the inpatient episode in RICU, as defined by detection of MRSA by conventional culture methods in screening swabs of nose and groin, or in clinical specimens processed by the laboratory in the course of normal clinical care. This will be measured on discharge from the ICU.
- Secondary Outcome Measures
Name Time Method All measured on discharge from the ICU:<br>1. Cost-effectiveness of regular use of 5% TTO body wash in this context<br>2. MRSA bacteraemia rates<br>3. Consumption of antibiotics used for the treatment of MRSA infection<br>4. Changes in the Sequential Organ Failure Assessment (SOFA) score during ICU stay