MedPath

Decitabine Versus Supportive Care in Adults With Advanced-stage MDS

Phase 3
Completed
Conditions
Myelodysplastic Syndrome
Registration Number
NCT00043381
Lead Sponsor
Astex Pharmaceuticals, Inc.
Brief Summary

To compare the safety and efficacy profiles of decitabine to those of supportive care in adults with advanced-stage myelodysplastic syndrome (MDS)

Detailed Description

This experimental (investigational) study is intended to answer the question of whether decitabine is any better than supportive care alone in delaying progression (worsening) of the disease, prolonging survival or improving the overall quality of life for MDS patients who are not candidates for bone marrow transplant (BMT).

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
160
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (24)

University of Illinois at Chicago

🇺🇸

Chicago, Illinois, United States

Alta Bates Comprehensive Cancer Center

🇺🇸

Berkeley, California, United States

Scripps Clinic

🇺🇸

Escondido, California, United States

Loma Linda Univ. Cancer Center

🇺🇸

Loma Linda, California, United States

New England Medical Center Hospital

🇺🇸

Boston, Massachusetts, United States

Roswell Park Cancer Institute

🇺🇸

Buffalo, New York, United States

Memorial Sloan Kettering Cancer Center

🇺🇸

New York, New York, United States

Mount Sinai Medical Center

🇺🇸

New York, New York, United States

UNC Lineberger Comprehensive Cancer Center

🇺🇸

Chapel Hill, North Carolina, United States

The Memphis Cancer Center

🇺🇸

Memphis, Tennessee, United States

SW Regional Cancer Center (dba Central Texas Oncology Associates)

🇺🇸

Austin, Texas, United States

Texas Oncology

🇺🇸

Dallas, Texas, United States

Univ. California San Francisco Medical School

🇺🇸

San Francisco, California, United States

VA Medical Center

🇺🇸

Minneapolis, Minnesota, United States

Duke University Medical Center

🇺🇸

Durham, North Carolina, United States

MD Anderson Cancer Center

🇺🇸

Houston, Texas, United States

University of Massachusetts Medical School

🇺🇸

Worcester, Massachusetts, United States

University of Florida

🇺🇸

Gainesville, Florida, United States

City of Hope National Medical Center

🇺🇸

Duarte, California, United States

Washington Univ. School of Medicine

🇺🇸

Saint Louis, Missouri, United States

Rush Medical Center

🇺🇸

Chicago, Illinois, United States

Dana Farber Cancer Institute

🇺🇸

Boston, Massachusetts, United States

H. Lee Moffitt Cancer Center

🇺🇸

Tampa, Florida, United States

James A. Haley Veteran's Hospital

🇺🇸

Tampa, Florida, United States

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