Het acute effect van beta-guanidinopropionzuur en creatine

Completed

Conditions: In this randomized, placebo controlled, double blind trial, we will assess the acute effect of the food supplements beta-guanidinopropionic acid and creatine in healthy men.Keywords: Healthy volunteers, creatine, beta-guanidinopropionic acid, tolerability, blood pressure, haemodynamics, ADP-dependent platelet aggregation.In Dutch: gezonde vrijwilligers, creatine, beta-guanidinopropionzuur, tolerantie, bloeddruk, haemodynamiek, ADP-afhankelijke plaatjesaggregatie.

Registration Number: NL-OMON26749

Lead Sponsor: The principal investigator is the study sponsor

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 24

Inclusion Criteria

Healthy men, 18-50 years old, with a body mass index from 18.5 to 29.9 kg/m2

Exclusion Criteria

glucose, lipid spectrum, thyroid, kidney, or liver abnormalities, (history of) cardiovascular disease including TIA and stroke; CK-increasing drugs including statins; use of acetylsalicyl acid or non-steroidal anti-inflammatory drugs (NSAIDs) in the two week prior to the visits, neuromuscular or endocrine disorders; vasculitis; HIV infection; infectious hepatitis; personal or family history of bleeding disorders, sickle cell disease; smoking; current use or use within 2 months prior to start of the trial of beta-guanidinopropionic acid or creatine.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tolerability of GPA after oral administration in healthy male volunteers versus placebo

Secondary Outcome Measures

Name	Time	Method
Hemodynamic parameters (Resting blood pressure; heart rate, cardiac output and total peripheral resistance, measured non-invasively) and ADP-induced platelet aggregation after oral administration of GPA in healthy male volunteers versus placebo and creatine. <br> <br>