The efficiency of continuous intrafemoral perfusion of PRP combine with the therapy of promoting blood circulation to C1 type femoral head necrosis preservatio
- Conditions
- Osteonecrisis of the femoral head
- Registration Number
- ITMCTR1900002647
- Lead Sponsor
- The First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) Aged 18-55 years, male or female, non-traumatic femoral head necrosis;
(2) X-ray of the hip joint is showing C1 type femoral head necrosis;
(3) Patients with ARCO stage of ONFH who are stage II with significant pain and patients with stage IIIA with pain or limited mobility;
(4) The affected femoral head did not collapse or collapsed less than 4mm, the joint space was not significantly narrow, and the head-to-head matching relationship was good;
(5) The patient agrees to participate in the trial and sign an informed consent form.
(1) Patients with other diseases that affect the progression of ONFH (such as major diseases of heart, lung, liver and kidney system, nephrotic syndrome, systemic lupus erythematosus, etc. still need to take hormones) and are in active period;
(2) Subjects suffering from hip or surrounding fractures, infections, tumors, etc. during the trial;
(3) Subjects with serious adverse reactions during the test;
(4) The investigator believes that it is not appropriate to continue to participate in the subjects of this clinical trial.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Femoral head cartilage thickness;Vascular evaluation;Later sidewall thickness;Collapse rate;Harris score;Bone marrow edema;
- Secondary Outcome Measures
Name Time Method Hip mobility;VAS score;Blood analysis;Coagulation four;Bone metabolism index;SF-12 score;