NL-OMON53601尚未招募不适用
High Flow Nasal Oxygen Therapy re-evaluated from a conceptual point of view: Effect on Respiratory Effort and Lung Aeration after Extubation - T-REX: Effect of HFNO Therapy on Respiratory Effort after Extubation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 54
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Aged >= 18 years
- •- Receiving invasive mechanical ventilation >48 hours for any cause
- •- Scheduled for extubation as per local clinical guideline
- •- Provided informed consent
排除标准
- •- Any clinical situation preventing appropriate execution of study procedures,
- •o Severe agitated delirium
- •o Do not reintubate order
- •- The presence of a tracheostomy
- •- Respiratory acidosis, defined as a pH <7.32 with hypercapnia (PCO2 >6.5 kPa /
- •PCO2 > 50 mmHg) during or after SBT
- •- Any feature that prohibits HFNO-initiation
- •o Recent facial upper-airway surgery
- •o Anatomic abnormalities that preclude appropriate fitting of HFNO
- •o Current exacerbation of obstructive pulmonary disease
- •- Obstructive/central Sleep Apnoea Syndrome or Obesity Hypoventilation Syndrome
- •in medical history
- •- Contra-indication for nasogastric tube or inability to perform adequate PES
- •measurements, e.g.:
- •o Recent esophageal surgery
- •o Prior esophagectomy
- •o Known presence of esophageal varices
- •o Severe bleeding disorders
- •- Known diaphragm paralysis defined as elevated hemi-diaphragm on X-ray or
- •evidence of paralysis during ultrasound (i.e. paradoxal diaphragm movement
- •during sniffing)
- •- Known pregnancy or current breast-feeding
研究者
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