To investigate patient's outcome using different hemofilter materials in those with sepsis associated acute renal failure

Not Applicable

Terminated

Conditions: Severe sepsis
Acute kidney injury
Renal and Urogenital - Kidney disease
Infection - Other infectious diseases

Registration Number: ACTRN12611000652976

Lead Sponsor: Department of intensive care, Pamela Youde Nethersole Eastern Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Stopped early

Sex: All

Target Recruitment: 120

Inclusion Criteria

1.Severe sepsis (defined based on ACCP/ SCCM criteria, ie Systemic Inflammatory Response Syndrome in the presence of suspected or known infection, leading to organ dysfunction), and
2.Acute kidney injury (defined based on RIFLE criteria, Injury” grade or above, who required continuous venovenous hemofiltration support)

Exclusion Criteria

1.Contraindication for regional citrate anticoagulation (Liver failure or cirrhosis with impaired citrate metabolism, allergy to citrate)
2.Pregnancy
3.Terminal illness

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality[28 days]

Secondary Outcome Measures

Name	Time	Method
ength of stay in hospital[Hospital discharge time];Sequential Organ Failure Assessment (SOFA) score[Daily until death or discharge from ICU];Best mean arterial pressure (MAP)[Daily until death or discharge from ICU];Vasopressor dosage[Daily until death or discharge from ICU];Best Oxygenation (PaO2/FiO2 ratio) based on arterial blood gas results and oxygen concentration provided via oxygen cannula or ventilator[Daily until death or discharge from ICU];Urine output based on all urinary catheter output charting[Daily until death or discharge from ICU];Length of stay in intensive care unit (ICU)[ICU discharge time]