A study of genetic and environmental factors associated with kidney disease in people of African ancestry living in the UK
- Conditions
- Exploration of genetic and environmental factors associated with chronic kidney disease in patients of African ancestryUrological and Genital Diseases
- Registration Number
- ISRCTN17433656
- Lead Sponsor
- King's College Hospital NHS Foundation Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 240
CKD cases:
1. Self-reported African ancestry
2. Aged =18 years
3. Willing and able to provide written informed consent
4. Chronic kidney disease (KDIGO Criteria)
5. Group 1: Without diabetic nephropathy or serological or biopsy-proven evidence of immune-mediated kidney disease
6. Group 2: With diabetic nephropathy or serological or biopsy-proven evidence of immune-mediated kidney disease
Controls:
1. Self-reported African ancestry
2. Aged =18 years
3. Willing and able to provide written informed consent
4. No CKD (estimated GFR >60 ml/min/1.73m² and urinary protein: creatinine <15mg /mol or albumin: creatinine ratio <3 mg/mmol or negative urine dip for protein).
For both CKD cases and controls:
1. Unable to provide informed consent
2. Pregnancy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method At a single time point:<br>1. APOL1 promoter DNA methylation patterns in renal tissue and PBMC (spleen) and urine (Cases only) measured using standard laboratory analysis<br>2. CKD disease phenotype measured using standard laboratory analysis
- Secondary Outcome Measures
Name Time Method At a single time point:<br>Clinical characteristics from patient notes and laboratory records, inflammatory markers measured using novel proteomic methods