Rate of Venous Thrombosis in Acutely Ill Patients Hospitalized in Internal Medicine Wards
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Venous thrombo-embolism
研究概览
简要总结
After reports from observational studies suggesting an association between acutely ill medical patients and venous thromboembolism (VTE), interventional trials with anticoagulants drugs have demonstrated a significant reduction of VTE during and immediately after hospitalisation. Although several guidelines suggest the clinical relevance of reducing this outcome, there is a low tendency to use anticoagulants in patients hospitalised for acute medical illness. This observational multicentre study wants to evaluate the incidence of venous thrombo-embolism in acutely ill patients hospitalized in internal medicine wards.
详细描述
Epidemiological studies have provided evidence of a high rate of thromboembolism in patients hospitalised in medical wards. Based on this, several clinical trials with anticoagulants including low-molecular-weight heparin (LMWH) and fondaparinux have been performed in patients hospitalised for acute medical illness to prevent thromboembolism. Interventional trials consistently showed that prophylaxis with anticoagulants reduces the risk of composite endpoints of deep venous thrombosis (DVT), pulmonary embolism (PE) and DVT-related death. These results prompted recommendation to the use anticoagulant prophylaxis in patients hospitalised for acute medical illness, but, despite this, there is a widespread underuse of anticoagulant prophylaxis in the medical wards of hospitals.
This observational multicentre study wants to evaluate the incidence of venous thrombo-embolism in acutely ill patients hospitalized in internal medicine wards.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pneumonia
- •heart failure
- •Chronic Obstructive Pulmonary Disease
- •Kidney failure
- •atrial fibrillation
- •Urinary Tract Infection
- •arthritis
- •Diabetic Ketoacidosis
- •unstable angina
- •cirrhosis
排除标准
- •treatment with vitamin k inhibitors
- •surgical interventions
- •deep venous thrombosis
- •pulmonary embolism
研究组 & 干预措施
Medical Patients
Medical patients who received, at admission and during all the length of recovery, antithrombotic drugs (low-molecular-weight heparin at prophylactic dosage ).
干预措施: low-molecular-weight heparin (Drug)
结局指标
主要结局
Venous thrombo-embolism
时间窗: Baseline, up to 4 weeks
Evaluation of deep venous thrombosis by compression ultrasonography (CUS)
次要结局
未报告次要终点
研究者
Francesco Violi
Principal Investigator, Clinical Professor, MD
University of Roma La Sapienza