Effect of opioids on heart under general anaesthesia

Not Applicable

• Conditions: Condition 1: conduction disorder. Condition 2: General anesthesia.; Other specified conduction disorders; Cardiac arrest, unspecified

• Registration Number: IRCT201210172310N2
• Lead Sponsor: Shiraz university of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Age between 18-35 years; ASA - PS ( American Society of Anesthesiologist- Physical Status) : I ; Elective ENT ( Ear-Nose-Throat ) operation under general anesthesia.
Exclusion criteria : Abnormal serum electrolytes, cardiovascular or psychiatric problems; idiopathic or acquired prolonged QT interval;anticipated difficulty in tracheal intubation ; patients taking any medication affecting QTc interval ( e.g. :tricylic antidepressant ,antidysrhythmics, ß-adrenergic antagonists, calcium channel blockers); existence of cardiac valvular disease; any cardiac rhythm abnormality; diabetes mellitus ; pregnancy ; obesity ( body mass index > 30 ) and hypersensitivity reaction to egg, fish or soya bean .

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
QT interval. Timepoint: Before and 90 seconds after induction of anesthesia, 1 and 5 minutes after endotracheal intubation. Method of measurement: Electrocardiograph.

Secondary Outcome Measures

Name	Time	Method
Heart rate. Timepoint: Before and 90 seconds after induction of anesthesia, 1 and 5 minutes after endotracheal intubation. Method of measurement: Operating room monitor.;Blood pressure. Timepoint: Before and 90 seconds after induction of anesthesia, 1 and 5 minutes after endotracheal intubation. Method of measurement: Operating room monitor.