Cardiac-CT in the Treatment of Acute Chest Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 600
- 试验地点
- 2
- 主要终点
- combined endpoint of: Cardiac death, myocardial infarction, unstabile angina, revascularisation, readmissions for chest pain
研究概览
简要总结
Objectives The CATCH trial (CArdiac cT in the treatment of acute CHest pain) is a prospective randomized controlled trial designed to evaluate the clinical value of cardiac multidetector computed tomography (MDCT) as a first-line diagnostic strategy in patients with acute chest pain, compared to a conventional functional-based testing strategy.
Methods:
Consecutive patients admitted with acute chest pain of suspected cardiac origin, but normal electrocardiogram and biomarkers were randomized to evaluation with 320-MDCT coronary angiography (CT-guided group) or with standard bicycle exercise test and/or myocardial perfusion imaging - MPI (Control group).
After one year, patients will be followed-up, with registration of clinical endpoints such as Cardiac death, myocardial infarction, need for revascularisation, admittance for heart related problems, sustained chest pain, live quality score, use of medication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admittance because of Chest pain
- •Non- or non-diagnostic ecg-changes.
- •Normal biomarkers for ischemia (Troponins)
- •Chest X-ray without pathological findings associated with chest pain.
排除标准
- •Women of childbearing age, or > 40 years and using approved contraception.
- •Claustrophobia
- •Patients with geographical residence, that complicates follow-up
- •Patients with mental or physical conditions that impede follow-up
- •Increase in Troponins
- •New diagnostic ECG changes with ST-segment elevation or depression greater than 1mm or T-yew inversion> 4 mm in> 2 anatomically connected derivations.
- •Allergy to iodinated contrast agents
- •Serum creatinine greater than 130 mg/l
- •Abnormal chest x-ray or blood tests hospitalization as assessed as the main cause of the patient's pain problem.
结局指标
主要结局
combined endpoint of: Cardiac death, myocardial infarction, unstabile angina, revascularisation, readmissions for chest pain
时间窗: 1 year follow-up
次要结局
- Cardiac death(1 year follow-up)
- myocardial infarction(1 year follow-up)
- readmissions for chest pain(1 year follow-up)
- Revascularisation(1 year follow-up)
- unstabile angina(1-year follow-up)
- continued chest pain(1 year follow-up)
- downstream testing(1-year follow-up)
- Quality of life (SF-36)(1-year follow-up)
- medication(1-year follow-up)
- non-cardiac findings on CT(1-year follow-up)
研究者
Jens D Hove, MD,PHD
Chief of Cardiac CT, MD,PHD
Hvidovre University Hospital