Cardiac-CT in the Treatment of Acute Chest Pain

Not Applicable

Completed

• Conditions: Ischemic Heart Disease
• Interventions: Procedure: Cardiac computed tomographic angiography (CCTA)

• Registration Number: NCT01534000
• Lead Sponsor: Hvidovre University Hospital

Brief Summary

Objectives The CATCH trial (CArdiac cT in the treatment of acute CHest pain) is a prospective randomized controlled trial designed to evaluate the clinical value of cardiac multidetector computed tomography (MDCT) as a first-line diagnostic strategy in patients with acute chest pain, compared to a conventional functional-based testing strategy.

Methods:

Consecutive patients admitted with acute chest pain of suspected cardiac origin, but normal electrocardiogram and biomarkers were randomized to evaluation with 320-MDCT coronary angiography (CT-guided group) or with standard bicycle exercise test and/or myocardial perfusion imaging - MPI (Control group).

After one year, patients will be followed-up, with registration of clinical endpoints such as Cardiac death, myocardial infarction, need for revascularisation, admittance for heart related problems, sustained chest pain, live quality score, use of medication.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2011-12-22
• Study First Submitted QC: 2012-02-15
• Study First Posted: 2012-02-16
• Primary Completion: 2014-01
• Study Completion: 2014-01
• Status Verified: 2014-06
• Last Update Submitted: 2014-06-18
• Last Update Posted: 2014-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• Admittance because of Chest pain
• Non- or non-diagnostic ecg-changes.
• Normal biomarkers for ischemia (Troponins)
• Chest X-ray without pathological findings associated with chest pain.

Exclusion Criteria

• Women of childbearing age, or > 40 years and using approved contraception.
• Claustrophobia
• Patients with geographical residence, that complicates follow-up
• Patients with mental or physical conditions that impede follow-up
• Increase in Troponins
• New diagnostic ECG changes with ST-segment elevation or depression greater than 1mm or T-yew inversion> 4 mm in> 2 anatomically connected derivations.
• Allergy to iodinated contrast agents
• Serum creatinine greater than 130 mg/l
• Abnormal chest x-ray or blood tests hospitalization as assessed as the main cause of the patient's pain problem.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CT guided group	Cardiac computed tomographic angiography (CCTA)	For Patients with chest pain randomised to this arm, clinical decision will be based on the results of a Cardiac computed tomographic angiography (CCTA)

Primary Outcome Measures

Name	Time	Method
combined endpoint of: Cardiac death, myocardial infarction, unstabile angina, revascularisation, readmissions for chest pain	1 year follow-up

Secondary Outcome Measures

Name	Time	Method
continued chest pain	1 year follow-up
unstabile angina	1-year follow-up
Cardiac death	1 year follow-up
myocardial infarction	1 year follow-up
readmissions for chest pain	1 year follow-up
Revascularisation	1 year follow-up
downstream testing	1-year follow-up
Quality of life (SF-36)	1-year follow-up
medication	1-year follow-up
non-cardiac findings on CT	1-year follow-up

Trial Locations

Locations (1)

Hvidovre University Hospital; 🇩🇰 Hvidovre, Denmark