Evaluation of the efficacy and safety of MRI guided focused ultrasound (MRgFUS) for focal hand dystonia

St Vincent's Health Network Sydney0 个研究点目标入组 11 人开始时间: 2022年5月31日最近更新: 2024年4月15日

试验速览

暂无简介。

•Patients will be included based on a formal diagnosis of focal hand dystonia (of either musician’s dystonia or writer’s subtype) as made by a consultant neurologist with specialisation in movement disorders. All patients must be at least 18 years of age and be willing to provide written consent to participate in the study. Patients must have tried and failed first line therapies for focal hand dystonia including hand therapy, oral medications and/or botulinum toxin injections.
•All patients must be ambulant at the time of the procedure.

•Patients will be excluded if any of the following criteria are fulfilled
•History of ischaemic stroke or transient ischaemic event
•History of stereotactic cerebral surgery
•Diagnosis of unstable cardiac disease
•Diagnosis of psychiatric disease
•Cognitive impairment as indicated by a mini-mental state examination score of < 24
•Coagulopathy or on anticoagulation that cannot be withheld for the intervention
•Skull density ratio of <0.3
•Absolute contraindication to MRI (eg: non-MR compatible pacemaker/defibrillator or other non-MR compatible device in situ).
•Relative contraindication to MRI (such as severe claustrophobia) will be assessed on a case-by-case basis
•Unwilling to provide written consent

发起方

St Vincent's Health Network Sydney