Corneal neurotization : Clinical outcome and confocal microscopic study of neurotrophic keratopathy after contralateral V1 transposition surgery

Not Applicable

Completed

• Conditions: - Patient who diagnosed CN7&CN5 palsy with Neurotrophic keratopathy- NK stages 2 and 3 (Mackie' s classification)- Confocal microscopic study; Neurotrophic keratopathy; Corneal neurotization

• Registration Number: TCTR20180627002
• Lead Sponsor: /A

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-01-09
• Study Start: 2018-06-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

- Patient who diagnosed CN7&CN5 palsy with Neurotrophic keratopathy
- NK stages 2 and 3 (Mackie's classification)
- Patient older than 18 years old
- Non-response to maximal medical and surgical treatment such as lachrymal substitution, tarsorrhaphy and gold weight implantation
- No ocular hypertony in both eyes
- Written consent of the patient

Exclusion Criteria

- Impossibility of general anesthesia
- Herpetic or zoster recurrence in the 6 months prior surgery
- Congenital or Bilateral NK
- Patient who had diagnosed isolated CN7 palsy or isolated CN5 palsy
- Other causes of NK : diabeta mellitus, amylosis, sarcoidosis, multiple sclerosis, vitamin A or B12 deficiency, Sjögren syndrome, GVH disease, topical NSAID, topical beta-blockers, history of refractive surgery.
- Mental illness
- Patient's unable to understand informations

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
What is the pattern of nerve which regenerate to cornea after we performed corneal neurotization Mar 2018 The laser-scanning confocal microscope (HRT3)

Secondary Outcome Measures

Name	Time	Method
How to evaluate clinical outcome in patients after corneal neurotization Mar 2018 modified Cochetâ€Bonnet esthesiometer