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Clinical Trials/ISRCTN07355119
ISRCTN07355119
Completed
Phase 3

A randomised trial to evaluate whether treatment can be reduced without compromising effficacy in a low risk group of patients defined by a molecular minimal residual disease (MRD) technique; and to evaluate whether further post-remission intensification can improve outcome for a MRD-defined high risk group

niversity of Sheffield (UK)0 sites2,500 target enrollmentAugust 18, 2003
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ConditionseukaemiaCancerLymphoid leukaemia

Overview

Phase
Phase 3
Intervention
Not specified
Conditions
eukaemia
Sponsor
niversity of Sheffield (UK)
Enrollment
2500
Status
Completed
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/23395119 2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/24904116 2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/24924991 2017 retrospective observational analysis in: http://www.ncbi.nlm.nih.gov/pubmed/28982824 2018 results in: http://www.ncbi.nlm.nih.gov/pubmed/29519867 (added 02/08/2019)

Registry
who.int
Start Date
August 18, 2003
End Date
June 30, 2011
Last Updated
6 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversity of Sheffield (UK)

Eligibility Criteria

Inclusion Criteria

  • •Children aged 1 \- 18 years with ALL
  • •As of 12/02/2010, young adults up to their 25th birthday are also eligible for this trial.

Exclusion Criteria

  • •1\. Mature B ALL
  • •2\. Infant ALL (aged less than 1 year)
  • •3\. Philadelphia positive ALL

Outcomes

Primary Outcomes

Not specified

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