A study evaluating the predictors of response to iTBS in patients with treatment resistant depressio
- Registration Number
- CTRI/2021/04/032678
- Lead Sponsor
- All India Institute of Medical Sciences New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 25
1.Right-handed
2.Willing to give written informed consent
3.Meeting DSM5 criteria for Major Depressive Disorder(MDD)
4.Suffering from TRD i.e. failed to response to at least 2 antidepressant medication trials given for at least 6-8 weeks at adequate dose
5.Hamilton Depression Rating Scale score >17 (moderate to severe depression)
1.Suffering from any other psychiatric disorder or substance use disorder(except caffeine or nicotine) through MINI 7.0 screening
2.History of epileptic seizures
3.Pregnancy/Lactation
4.History of neurological disorders or substantial brain damage
5.Any present uncontrolled medical condition
6.Contraindication to magnetic fields, according to established safety criteria as per Rossi et al 2009 study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in PET/CT scanTimepoint: Assessment will be done at baseline, at 1 week after 5th session of rTMS and at 3 weeks after last session
- Secondary Outcome Measures
Name Time Method Change in HAMD scoreTimepoint: Assessment will be done at baseline, at 1 week after 5th session of rTMS and at 3 weeks after last session