The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
- Conditions
- Autism Spectrum Disorder
- Interventions
- Behavioral: PEERS
- Registration Number
- NCT05884853
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
- age between 18 and 50
- diagnosed with ASD from licensed mental health or medical professional based on DSM5
- have social problems
- motivated to participate in the treatment
- fluent in chinese
- caregiver also fluent in chinese and motivated to participate
- had a full-scale IQ > 70 on WAIS-IV
- scored ≧ 26 on the caregiver-reported Autism Spectrum Quotient (AQ), indicating clinical impairment associated with ASD.
- history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases
- visual impairment and/or hearing impairment
- any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fMRI scan.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ASD group PEERS autistic adolescents with their caregiver Control group PEERS healthy control without their caregiver
- Primary Outcome Measures
Name Time Method Autism Diagnostic Interview Revised, ADIR 16 weeks Interview of the caregivers that covers most developmental and behavioral aspects of ASD. Range from 0 to 8, higher the score, worse the symptom.
The Empathy Quotient (EQ) 16 weeks 40 items, total score range from 0 to 80. Higher the score, worse the empathy
The Autism Diagnostic Observation Schedule, ADOS 16 weeks Diagnosing and assess autism. Range from 0 to 8, higher the score, worse the symptom.
Autism Spectrum Quotient 16 weeks 50 items, total score range from 0 to 50. Higher the score, worse the symptom
Social Responsiveness Scale, Second Edition (SRS-2) 16 weeks 65 items, total score range from 65 to 260. Higher the score, worse the symptom
Quality of Socialization Questionnaire (QSQ) 16 weeks 12 items, total score range from 0 to 12.Higher the score, better the frequency and quality of socialization
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Taiwan University Hospital
🇨🇳Taipei, Zhongzheng Dist., Taiwan