Characteristics and Outcomes of Patients With COVID-19 Admitted to the ICU
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,589
- 试验地点
- 1
- 主要终点
- ICU survival at 28 days
研究概览
简要总结
This is a case series of patients with COVID-19 admitted to the largest university hospital in Sao Paulo, Brazil, during the 2020 COVID-19 pandemic. Data will be collected prospectively and retrospectively.
The main objective is to describe the characteristics of critically ill patients with COVID-19 and their clinical outcomes, and to identify risk factors associated with survival, to inform clinical decision-making and to guide the strategy to mitigate the epidemic, both within each hospital and ICU and in public health management.
详细描述
In December 2019, an outbreak of Severe Acute Respiratory Syndrome (SARS) attributed to a new coronavirus, called SARS-CoV-2, was described in the Wuhan region of China. This SARS, caused by SARS-CoV-2 was called COVID-19, spread across the globe, causing millions of cases on all continents, and thousands of deaths, being characterized as a pandemic.
COVID-19 is characterized by a flu-like syndrome, with symptoms such as fever, cough, myalgia and gastrointestinal symptoms. Most cases are mild, some even asymptomatic, but approximately 15% of patients have more severe presentation, and approximately 5% are critical (7).
The acute respiratory failure of critically ill patients with COVID-19 has different aspects, including hypoxemia of difficult treatment, associated in some cases with clotting disorders, changes in immunity and inflammatory phenomena that pose challenges for the management of these patients, whose mortality can be high.
The Hospital das Clínicas da Faculdade de Medicina de São Paulo implemented an action plan that provides for the creation of 200 ICU beds to serve patients with COVID-19. Knowing the characteristics of critically ill patients with COVID-19 and their clinical outcomes is extremely important to inform clinical decision-making and to guide the strategy to mitigate the epidemic, both within each hospital and ICU and in public health management.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 年龄范围
- 14 Years 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being admitted to one of the COVID-19 ICUs during the study period
- •Suspected or confirmed COVID-19
- •Expected ICU stay greater than 24 hours
排除标准
- •ICU Readmission during the same hospital stay (patients will be evaluated only during their first ICU stay)
结局指标
主要结局
ICU survival at 28 days
时间窗: 28 days
the proportion of patients who survive to ICU discharge or for 28 days in the ICU
次要结局
- Hospital survival at 60 days(60 days)
- Duration of mechanical ventilation(28 days)
- Need for renal replacement therapy(28 days)
- Complications during the ICU stay(28 days)
研究者
Juliana Carvalho Ferreira
Assistant professor
University of Sao Paulo General Hospital