Effect of Walking on Brain Fuel Consumption in Mild Alzheimer's Disease
- Conditions
- Alzheimer's Disease
- Registration Number
- NCT02708485
- Lead Sponsor
- Université de Sherbrooke
- Brief Summary
The aim of this study is to evaluate the effect of a 3-month walking program on brain energy metabolism in patient with mild Alzheimer's disease (AD). Two groups of sedentary patients with mild AD are followed and compared over a 3-month period of time: Control (non-active) and walking (from 15 to 45 minutes of exercise on a treadmill, 3 times a week for 12 weeks) groups. All the participants are evaluated on their cognition, brain volumes (MRI) and brain fuel consumption (PET scan with 18-FDG and 11C-AcAc) at the beginning and at the end of the study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
- Diagnosis of mild Alzheimer's disease (NINCDS-ADRDA criteria)
- Taking cholinesterase inhibitors
- Sedentary
- Ability to do physical exercise
- Parkinson disease
- Down syndrome
- Epilepsy or concussion
- Drug or alcohol abuse
- Past psychiatric history
- Vitamin B12 Deficiency
- Uncontrolled diabetes or thyroid function
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Brain Glucose Consumption 3 months Brain glucose uptake (umol/100g/min) using 18F-FDG PET imaging
Brain Acetoacetate Consumption 3 months Brain acetoacetate uptake (umol/100g/min) using 11C-AcAc PET imaging
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)
🇨🇦Sherbrooke, Quebec, Canada
Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)🇨🇦Sherbrooke, Quebec, Canada