Evaluating the Impact of Physical Exercise on Mild Alzheimer's Disease in a Randomized Clinical Trial: Quantification With 18F -FDG and 11C- AcAc PET Imaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Brain Glucose Consumption
研究概览
简要总结
The aim of this study is to evaluate the effect of a 3-month walking program on brain energy metabolism in patient with mild Alzheimer's disease (AD). Two groups of sedentary patients with mild AD are followed and compared over a 3-month period of time: Control (non-active) and walking (from 15 to 45 minutes of exercise on a treadmill, 3 times a week for 12 weeks) groups. All the participants are evaluated on their cognition, brain volumes (MRI) and brain fuel consumption (PET scan with 18-FDG and 11C-AcAc) at the beginning and at the end of the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of mild Alzheimer's disease (NINCDS-ADRDA criteria)
- •Taking cholinesterase inhibitors
- •Sedentary
- •Ability to do physical exercise
排除标准
- •Parkinson disease
- •Down syndrome
- •Epilepsy or concussion
- •Drug or alcohol abuse
- •Past psychiatric history
- •Vitamin B12 Deficiency
- •Uncontrolled diabetes or thyroid function
研究组 & 干预措施
Control group
No intervention
Physical exercise
A 3-month walking program (3 times a week for 12 weeks) on treadmill supervised by a physiotherapist. Duration of the exercise is progressively increased from 15 min to 45 min over a 6-week period and the intensity of the exercise is moderate (a 12-13 score on Borg scale).
干预措施: Physical exercise (Other)
结局指标
主要结局
Brain Glucose Consumption
时间窗: 3 months
Brain glucose uptake (umol/100g/min) using 18F-FDG PET imaging
Brain Acetoacetate Consumption
时间窗: 3 months
Brain acetoacetate uptake (umol/100g/min) using 11C-AcAc PET imaging
次要结局
未报告次要终点