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临床试验/NCT07465328
NCT07465328进行中(未招募)不适用

Studying the Impairment of Stroke and Sarcopenia Pa-tients Using Maximum Voluntary Contractions of the Leg Joints.

Vrije Universiteit Brussel1 个研究点 分布在 1 个国家目标入组 42 人开始时间: 2025年2月11日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
42
试验地点
1
主要终点
Obtaining maximum voluntary torques of the lower-limb joints for sarcopenia and stroke patients

研究概览

简要总结

The goal of this study is to obtain the maximum voluntary torques of the lower-limb joints and to monitor oxygen level in the main lower-limb muscles. This will be done for three joints: i.e. the hip, knee and ankle joint and NIRS sensors will be placed on the biceps femoris, rectus femoris and gastrocnemius muscle. For the hip and knee, the maximum torque will be determined both in exertion direction and flexion direction. For the ankle, both plantarflexion and dorsiflexion will be considered. For each of these directions, the maximum joint torque will be defined for different specific joint angles and joint velocities (see procedure). For every joint and for the whole protocol for the torques measurement campaign, the different muscle of interest will be monitored with the NIRS, i.e. hip is associated with hamstring contraction, knee is associated with thigh contraction and ankle is associated with calf contraction. With these discrete points, an algorithm will be used to obtain a complete plot of the maximum torque in function of both joint angle and joint velocities. Comparing these plots between for example stroke and healthy individuals can help us understand what level of assistance stroke patients require. Comparison in oxygen level between healthy individuals and impairments population of stroke and sarcopenia patients can also help us investigate how oxygen is used depending on the population.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Post stroke patients:
  • Must be 18+ years old
  • Must be three months or more after stroke diagnosis
  • Have difficulties with gait (FAC level 3-4)
  • Sarcopenia patients:
  • Must be 65+ years old
  • Not be able to perform five chair sit to stands within 15 seconds
  • Grip strength of less than 27 kg for men and less than 16 kg for females
  • Have difficulties with gait (SPPB ≤ 8)
  • Healthy participants:
  • No physical injuries that limits the torque production in lower-limb joints

排除标准

  • 未提供

研究组 & 干预措施

Measuring MVC's of participants

Experimental

干预措施: MVC measurements of participants (Other)

结局指标

主要结局

Obtaining maximum voluntary torques of the lower-limb joints for sarcopenia and stroke patients

时间窗: 2 years

The goal is to determine the maximum torque that each joint can produce in an isostatic case in the sagittal plane. Not only the amount of torque but also at which joint angle this manifests are important parameters that we would like to use for the design process of an exoskeleton. Furthermore, we'd like to obtain the change in maximum torque when transferring from an isostatic test to an isokinetic test. The higher the joint velocity, the more the torque will decrease. However, how much is this decrease? We expect that the decrease for increased joint velocities in the targeted populations will differ compared to healthy individuals

次要结局

  • Measuring muscle oxygenation(2 years)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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