Exercise in the Fasted State, Glucose Metabolism and Energy Balance

Not Applicable

Completed

• Conditions: Energy Balance; Blood Glucose
• Interventions: Behavioral: Exercise; Dietary Supplement: Breakfast

• Registration Number: NCT02258399
• Lead Sponsor: University of Bath

Brief Summary

The ability to control our blood glucose (sugar) concentrations after a meal is a strong predictor of the risk of disease. Our bodies respond to glucose ingestion by reducing the amount of glucose from the liver entering the bloodstream. At the same time muscle increases the amount of glucose it take up from the bloodstream. This ensures that our blood glucose levels do not get too high. The investigators want to understand what happens to these processes following exercise after breakfast and after an overnight fast. In addition, the investigators also want to understand whether exercising with or without breakfast influences our appetite, food intake and activity levels later in the day.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-10-02
• Study First Submitted QC: 2014-10-06
• Study First Posted: 2014-10-07
• Study Start: 2015-05
• Primary Completion: 2016-06
• Study Completion: 2017-12
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-30
• Last Update Posted: 2018-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• Males.
• Aged 18-49.
• Individuals free from known cardiovascular, metabolic or joint disease as determined by standard health questionnaire.
• Habitual regularly participating in exercise (minimum of 3 sessions per week on average)
• Non-smoker

Exclusion Criteria

• Known or suspected food intolerances, allergies or hypersensitivity.
• Any bleeding disorder or taking medication which impacts blood coagulation.
• Known tendency towards keloid scarring.
• Known sensitivity or allergy to any local anaesthetic medicines.
• Any reported use of substances which may pose undue personal risk to participants or introduce bias into the experiment.
• Any other condition or behaviour deemed either to pose undue personal risk to participants or introduce bias into the experiment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Fasted Exercise	Exercise	-
Breakfast Exercise	Exercise	-
Breakfast Rest	Breakfast	-
Breakfast Exercise	Breakfast	-

Primary Outcome Measures

Name	Time	Method
Exogenous glucose appearance rate	120 minutes	Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).
Energy balance	24 hours	Energy balance (intake minus expenditure) over 24 h from the beginning of the trial

Secondary Outcome Measures

Name	Time	Method
Glucose clearance rates	120 minutes	Glucose clearance rates following an oral glucose tolerance test (total clearance over 120 minutes).
Endogenous glucose appearance rates	120 minutes	Endogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).
Energy intake	24 h	Weighted energy intake over 24 hours from the beginning of the trial.
Exogenous glucose appearance rates	120 minutes	Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).
Energy expenditure	24 h	Energy expenditure, derived from indirect calorimetry, acccelerometry and heart rate monitoring.

Trial Locations

Locations (1)

Department for Health, University of Bath; 🇬🇧 Bath, United Kingdom