Exercise in the Fasted State, Glucose Metabolism and Energy Balance
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Bath
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Exogenous glucose appearance rate
Study Overview
Brief Summary
The ability to control our blood glucose (sugar) concentrations after a meal is a strong predictor of the risk of disease. Our bodies respond to glucose ingestion by reducing the amount of glucose from the liver entering the bloodstream. At the same time muscle increases the amount of glucose it take up from the bloodstream. This ensures that our blood glucose levels do not get too high. The investigators want to understand what happens to these processes following exercise after breakfast and after an overnight fast. In addition, the investigators also want to understand whether exercising with or without breakfast influences our appetite, food intake and activity levels later in the day.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 49 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Individuals free from known cardiovascular, metabolic or joint disease as determined by standard health questionnaire.
- •Habitual regularly participating in exercise (minimum of 3 sessions per week on average)
- •Non-smoker
Exclusion Criteria
- •Known or suspected food intolerances, allergies or hypersensitivity.
- •Any bleeding disorder or taking medication which impacts blood coagulation.
- •Known tendency towards keloid scarring.
- •Known sensitivity or allergy to any local anaesthetic medicines.
- •Any reported use of substances which may pose undue personal risk to participants or introduce bias into the experiment.
- •Any other condition or behaviour deemed either to pose undue personal risk to participants or introduce bias into the experiment.
Arms & Interventions
Breakfast Rest
Intervention: Breakfast (Dietary Supplement)
Breakfast Exercise
Intervention: Exercise (Behavioral)
Breakfast Exercise
Intervention: Breakfast (Dietary Supplement)
Fasted Exercise
Intervention: Exercise (Behavioral)
Outcomes
Primary Outcomes
Exogenous glucose appearance rate
Time Frame: 120 minutes
Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).
Energy balance
Time Frame: 24 hours
Energy balance (intake minus expenditure) over 24 h from the beginning of the trial
Secondary Outcomes
- Glucose clearance rates(120 minutes)
- Endogenous glucose appearance rates(120 minutes)
- Energy intake(24 h)
- Exogenous glucose appearance rates(120 minutes)
- Energy expenditure(24 h)
Investigators
Javier Gonzalez
Lecturer
University of Bath