Effect of traditional Chinese medicine on early renal injury in patients with chronic heart failure
- Conditions
- chronic heart failure
- Registration Number
- ITMCTR2100004621
- Lead Sponsor
- Guang'anmen Hospital, China Academy of Chinese Medicine Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
(1) Age from 30 to 80, gender unlimited;
(2) It meets the diagnostic criteria for CHF;
(3) Urine N-acetyl-ß-D-glucosaminosidase (NAG) > 12U/L, and estimated glomerular filtration rate (EGFR) BBB> mL /min/1.73m2;
(4) It meets the diagnostic criteria of the syndrome of insufficiency of spleen and Yang;
(5) the cardiac function class (NYHA) II - III;
(6) Signed the informed consent.
(1) Heart failure caused by valvular heart disease, congenital heart disease, myocarditis, cardiomyopathy, etc.;
(2) People who have been diagnosed with kidney disease;
(3) Severe arrhythmias, including frequent premature ventricular beats, grade II type II atrioventricular block, grade III atrioventricular block, and cardiogenic shock;
(4) Patients with severe hypertension and poor medication control (SBP >= 180mmHg and/or Diastolic blood pressure >= 110mmHg);
(5) Patients with severe liver function abnormalities (ALT or AST reaching more than 3 times the upper limit of normal value), endocrine diseases, malignant tumors and autoimmune diseases;
(6) Pregnant or lactating women;
(7) People with allergic constitution and drug components in this study;
(8) Participating in other clinical trials or participating in clinical trials of other drugs for less than one month.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AG;
- Secondary Outcome Measures
Name Time Method KIM-1;IgG;IGFBP7;LVEF;BUN;RBP;mALB;ß2-MG;a1-MG;Tf;Scr;NGAL;NT-proBNP;TIMP-2;