Hyponatraemia and Mortality in Schizophrenic and Bipolar Patients: Protocol for a Bayesian Causal Inference Study

• Conditions: Hyponatremia; SIADH
• Interventions: Other: Plasma sodium level (continuous variables)

• Registration Number: NCT04409626
• Lead Sponsor: Zealand University Hospital

Brief Summary

This study seeks to investigate if hyponatraemia be a direct contributor to death in schizophrenic and bipolar patients, and gauge the potential role of somatic comorbidity and psychotropic polypharmacy, with emphasis on antipsychotics and antidepressants.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01-01
• Status Verified: 2020-05
• Study First Submitted: 2020-05-27
• Study First Submitted QC: 2020-05-27
• Last Update Submitted: 2020-05-27
• Study First Posted: 2020-06-01
• Last Update Posted: 2020-06-01
• Primary Completion: 2020-07
• Study Completion: 2020-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 31740

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Controls	Plasma sodium level (continuous variables)	Matched (5 controls per case) by date of birth +/- 180 days.
Cases	Plasma sodium level (continuous variables)	-

Primary Outcome Measures

Name	Time	Method
Mortality	1 January 2011 through 1 July 2016	All-cause mortality