Does adding dexmedetomidine to a local anesthetic prolong the duration of a nerve block?

Conditions: Healthy volunteers (treatment intended for pain treatment in patientsafter knee surgery)
MedDRA version: 17.1Level: LLTClassification code 10054711Term: Postoperative painSystem Organ Class: 100000004863
Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]

Registration Number: EUCTR2014-005651-89-DK

Lead Sponsor: Køge Sygehus

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: Male

Target Recruitment: 20

Inclusion Criteria

Age >18
Men
ASA 1
BMI >18 and < 30
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 20
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 20

Exclusion Criteria

Allergy to study medication
Alcohol consumption >21 units of alcohol per week
Medical abuse (as judged by investigator)
Daily intake of perscription painkillers within the last 4 weeks
Intake of over the counter medication within 48 hours
Earlier trauma og surgery to lower limb
Diabetes mellitus
Heart block 2. og 3. degree
Sick sinus node

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: To investigate whether dexmedetomidine as an adjuvant to ropivacaine for<br>adductor canal block increases duration of the sensory block when<br>controlling for a systemic effect;Secondary Objective: not applicable;Primary end point(s): Difference in duration of sensory block between dexmedetomidine and placebo<br>assessed as cold sensation with an alcohol swab.;Timepoint(s) of evaluation of this end point: Duration is defined as time from block performance until recovery of<br>normal sensation to an alcohol swab, assessed every hour post block<br>(and every half hour when pain scores during the tonic heat stimulation<br>test is above zero ).

Secondary Outcome Measures