Bronchiolitis obliterans syndrome and other allo-reactive lung syndromes after allogeinic hematopoietic stem cell transplantation Is early prediction of bronchiolitis obliterans possible by using biomarkers possible?
Recruiting
- Conditions
- afstoting na beenmergtransplantatiechronic lung rejection bronchiolitis obliteranslung rejection after hematopoietic stemcell transplantation10038716
- Registration Number
- NL-OMON44102
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 360
Inclusion Criteria
Patients whom are selected for hematopoietic stem cell transplantation
Exclusion Criteria
no informed consent
all patients after hematopoietic stem cell transplantation will be included except patients that do not want to participate in this study.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Identifying biomarkers in the peripheral blood that predict BOS by a sgnificant<br /><br>elevation before a lungfunction decline occurs (i.e. a drop in FEV1 of 20%)<br /><br>after allogeneic hemtopoietic stem cell transplantation.<br /><br>. </p><br>
- Secondary Outcome Measures
Name Time Method <p>To determine the incidence and outcome of allo-reactive lung syndromes (i.e.<br /><br>BOS and other ARLS) in patients that underwent allogeneic haematopoietic stem<br /><br>cell transplantation.</p><br>