Effects of off pump versus on pump coronary surgery on reversible and irreversible myocardial injury: a randomised trial using cardiovascular magnetic resonance imaging and biochemical markers

Completed

• Conditions: CABG surgery; Circulatory System; Coronary diseases

• Registration Number: ISRCTN20472718
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-07-22
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Aged less than 75 years
2. Isolated coronary grafting

Exclusion Criteria

1. Age greater than 75 years (ten patients)
2. Ppre-existing Left Ventricular (LV) dysfunction (ejection fraction less than 20% by echocardiogram; four patients)
3. Involvement in other clinical trials (ten patients)
4. Typical MRI contraindications (e.g. pacemaker, severe claustrophobia etc.; total of nine patients)
5. Baseline creatinine more than 200 µmol/L (two patients)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Left ventricular function at one week post-op<br>2. LV function at six months post-op<br>3. Myocardial necrosis post-op

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures